Anti-plasma kallikrein B1 heavy chain antibody
| 英文名称 | plasma kallikrein B1 heavy chain |
| 中文名称 | 血浆激肽释放酶重链抗体 |
| 别 名 | Plasma Kallikrein 1B; Plasma kallikrein B1; EC 3.4.21.34; Fletcher factor; Kallikrein 3 plasma (Fletcher factor); kallikrein B plasma; Kallikrein B plasma (Fletcher factor) 1; Kallikrein B, plasma 1; Kininogenin; KLK3; KLKB1; KLKB1_HUMAN; Plasma kallikrein; Plasma prekallikrein; PPK; Prekallikrein; plasma kallikrein B1 heavy chain; Plasma kallikrein; Fletcher factor; Plasma kallikrein heavy chain. |
DATASHEET
Host:Rabbit
Target Protein:plasma kallikrein B1 heavy chain
IR:Immunogen Range:451-550/638
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3818
Swiss Prot:P03952
Source:KLH conjugated synthetic peptide derived from human plasma kallikrein B1 heavy chain:451-550/638
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample:
Hela(human)cell Lysate at 30 ug
Cerebrum(mouse) Lysate at 40 ug
K562(human)cell Lysate at 30 ug
liver(mouse) Lysate at 40 ug
Primary: Anti-plasma kallikrein B1 heavy chain (bs-5872R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41kD
Observed band size: 55 kD
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