Nogo-66 1-40 (NEP 1-40) Peptide (Y-0198P)

Nogo-66 1-40 (NEP 1-40) Peptide

Quantity size:

500ug

MW:

4.622kDa

Source:

Synthetic Peptide

Form:

lyophilized powde

Purity:

≥95% (Purified by HPLC)

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

Biological activity
Immunology research

Background:

Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.
Sequence: Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide
MW:4622.35

Also known as:

Nogo-66(1-40) antagonist peptide; NEP 1-40 peptide; Reticulon-4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.