PHD3 Peptide (bs-0532P)

PHD3 Peptide

Quantity size:

500ug

Source:

Synthetic Peptide

Form:

lyophilized powde

Purity:

≥95% (Purified by HPLC)

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

Blocking Peptide of The bs-0532R Antibody

Background:

bs-0532P is one synthetic peptide derived from human PHD3.
PHD3 (Egl nine homolog 3; Hypoxia-inducible factor prolyl hydroJNClase 3; HIF-prolyl hydroJNClase 3; HIF-PH3; HPH-1; Egln3; Prolyl hydroJNClase domain-containing protein 3;)Catalyzes the post-translational formation of 4-hydroJNCproline in hypoxia-inducible factor (HIF) alpha proteins. HydroJNClates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oJNCgen sensor and, under normoxic conditions, targets HIF through the hydroJNClation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism. [Catalytic Activity] An HIF alpha chain L-proline + 2-oxoglutarate+ O(2) = An HIF alpha chain trans-4-hydroJNC-L-proline + succinate + CO(2). [Subcellular Location] Cytoplasm. Nucleus. Widely expressed at low levels. Expressed athigher levels in heart (cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle) and placenta.

Also known as:

EGL9 homolog of C. elegans 3; EGLN3; Factor responsive smooth muscle protein; HIF Prolyl HydroJNClase 3; HIFP4H3; HIFPH3; P4H3; Prolyl HydroJNClase Domain Containing Protein 3; SM20.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.