thrombin/Prothrombin Peptide (bs-1914P)

thrombin/Prothrombin Peptide

Quantity size:

500ug

Source:

Synthetic Peptide

Form:

lyophilized powde

Purity:

،ف95% (Purified by HPLC)

Storage:

Shipped at 4،و, Store at -20،و (Avoid repeated freeze/thaw cycles).

Application:

Biological activity
Blocking Peptide of The bs-1914R Antibody

Background:

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Involvement in disease:
Defects in F2 are the cause of factor II deficiency (FA2D) . It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.
Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F2 are a cause of susceptibility to thrombosis (THR) . It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.

Also known as:

coagulation factor II; prothrombin; F2; Cf-2; Cf2; FII; F 2 antibody coagulation factor II (thrombin); Coagulation factor II; Coagulation factor II precursor; F2 antibody Factor II; Prothrombin; prothrombin B-chain; PT; serine protease; THRB; THRB_HUMAN; Thrombin; Thrombin heavy chain.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.