LPS (bs-8000P)

LPS

Quantity size:

10mg

Source:

Natural protein

Form:

lyophilized powde

Purity:

≥95% (Purified by HPLC)

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

Biological activity
Immunology research

Background:

Some form of LPS is a major component of the cell membrane of Gram negative bacteria, contributing greatly to the structural integrity of the bacteria, and protecting the membrane from certain kinds of chemical attack. LPS is an endotoxin, and induces a strong response from normal animal immune systems. LPS function has been under experimental research for several years due to its role in activating many transcriptional factors, which become active after stimulation with LPS. LPS also produces many types of mediators involved in septic shock.

Application:
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Lipopolysaccharide from Escherichia coli O55:B5 has been used:
? to stimulate hepatocytes and non-parenchymal cells.
? to stimulate the spleen and study the expression of the Malitaf gene in the fish blunt snout bream.
? as part of the concanavalin A (ConA) and D-galactosamine/lipopolysaccharide (D-GalN/LPS) model of fulminant hepatitis to study the effect of the natural compound hesperetin.

Also known as:

Lipopolysaccharides; LPSs; Escherichia coli LPS; E. coli LPS; Lipopolysaccharides(LPS); Lipopolysaccharides from Escherichia coli O55:B5; Lipopolysaccharides from Escherichia coli O55:B5 purified by phenol extractionLipopolysaccharides; Sigma L2880;

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.