Recombinant Human BMP-4 (Active,Tag free)
| 英文名称 | Recombinant Human BMP-4 (Active,Tag free) |
| 中文名称 | 重组人骨形态发生蛋白-4 (活性的, Tag free) |
| 别 名 | rhBMP-4; BMP 4; BMP2B; BMP2B1; Bone morphogenetic protein 4; DVR4; ZYME; BMP4_HUMAN; BMP-4; Bone morphogenetic protein 2B; BMP-2B. |
| 分 子 量 | 34-40kDa |
| 性 状 | lyophilized powder |
| 种属同源 | human |
| 序 列 | 293-408aa, Tag free, full length mature protein |
| 产品来源 | 基因工程表达 |
| 分 类 | 细胞因子 |
| 产品应用 | Biological activity Immunology research |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -80℃ under sterile conditions after reconstitution. |
| 产品介绍 | Bone morphogenetic protein 4 (BMP-4) is a member of transforming growth factor β family that includes more than 20 structurally related bone growth factors. BMP-4 is widely expressed from early embryogenesis through adulthood. It plays an important role in cartilage and bone formation, mesoderm induction, tooth development, limb formation and fracture repair. Mature human BMP-4 is a 116 amino acids glycoprotein and normally found as a homodimer. Dimerization is facilitated by a disulfide bridge formed between the monomer, which contains three intrachain disulfide bridges arranged in a cystine knot motif. BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPRIA) and type II (primarily Activin RIIA or BMPRII) receptors. The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans. |
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