Recombinant SARS-CoV-2 (2019-nCoV) Papain-Like Protease (bs-41432P)

Recombinant SARS-CoV-2 (2019-nCoV) Papain-Like Protease

Quantity size:

100ug

MW:

35.8kDa

Source:

Recombinant protein

Form:

lyophilized powde

Purity:

≥95% (Purified by HPLC)

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

Immunology research

Background:

Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.

Also known as:

Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.