Anti-SIRP Alpha antibody
| 英文名称 | SIRP Alpha |
| 中文名称 | 信号调节蛋白α抗体 |
| 别 名 | Signal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based activation motifs; Brain immunoglobulin like molecule with tyrosine based activation motifs; CD172 antigen like family member A; CD172a; CD172a antigen; Inhibitory receptor SHPS1; Macrophage fusion receptor; MFR; MYD 1; Myd 1; MYD1; p84;Protein tyrosine phosphatase non receptor type substrate 1; PTPNS1; SHP Substrate 1; SHPS1; Signal regulatory protein alpha 2; Signal regulatory protein alpha 3; Signal regulatory protein alpha; Signal Regulatory Protein Alpha Type 1; Signal regulatory protein alpha type 2; SIRP; SIRPA; SIRPalpha; SIRPalpha1; SIRPalpha2; SIRPalpha3; Tyrosine phosphatase SHP substrate 1; Tyrosine protein phosphatase non receptor type substrate 1; Tyrosine protein phosphatase non receptor type substrate; CD172a. |
DATASHEET
Host:Rabbit
Target Protein:SIRP Alpha
IR:Immunogen Range:151-250/504
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:140885
Swiss Prot:P78324
Source:KLH conjugated synthetic peptide derived from human CD172a:151-250/504
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Protein tyrosine phosphatases (PTPases) SHP1 and SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1),SHPS1 , MyD1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Flow-Cyt(1μg /test)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample:
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti-SIRP Alpha (bs-2708R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 56 kD
Sample:
Spleen(Mouse) Lysate at 30 ug
Bones (Mouse) Lysate at 30 ug
Primary: Anti- SIRP Alpha (bs-2708) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 53 kD
Sample:
Raw264.7(Mouse) Cell Lysate at 30 ug
Primary: Anti-SIRP Alpha (bs-2708R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 56 kD
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