Anti-CHMP4B+CHMP4C antibody
| 英文名称 | CHMP4B+CHMP4C |
| 中文名称 | 染色质修饰蛋白4B(4C)抗体 |
| 别 名 | SNF7 homolog associated with Alix 3; C20orf178; Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP 4B; CHMP 4C; CHMP4A; Chromatin modifying protein 4B; Chromatin modifying protein 4C; CTPP3; dJ553F4.4; hSnf7 2; hSnf7 3; hVps32; MGC22825; Shax1; Shax3; SNF7 2; SNF7 3; SNF7; Snf7 homologue associated with Alix 1; Vacuolar protein sorting associated protein 7 2; Vacuolar protein sorting associated protein 7 3. |
DATASHEET
Host:Rabbit
Target Protein:CHMP4B+CHMP4C
IR:Immunogen Range:101-200/224
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:128866 942421
Swiss Prot:Q9H444, Q96CF2
Source:KLH conjugated synthetic peptide derived from human CHMP4B/CHMP4C:101-200/224
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009].
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Rabbit
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Paraformaldehyde-fixed, paraffin embedded (rat lung tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CHMP4B+CHMP4C) Polyclonal Antibody, Unconjugated (bs-7744R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CHMP4B+CHMP4C) Polyclonal Antibody, Unconjugated (bs-7744R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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