Anti-CRMP3 antibody
| 英文名称 | CRMP3 |
| 中文名称 | 二氢嘧啶酶相关蛋白3抗体 |
| 别 名 | Collapsin response mediator protein 3; CRMP 3; CRMP-3; CRMP3; Dihydropyrimidinase like 4; Dihydropyrimidinase related protein 4; Dihydropyrimidinase-related protein 4; DPYL4_HUMAN; DPYSL4; DRP 4; DRP-4; DRP4; ULIP 4; ULIP-4; ULIP4; UNC33 like phosphoprotein 4; UNC33-like phosphoprotein 4. |
DATASHEET
Host:Rabbit
Target Protein:CRMP3
IR:Immunogen Range:6-100/572
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:10570
Swiss Prot:O14531
Source:KLH conjugated synthetic peptide derived from human CRMP3:6-100/572
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample:
Ovary(Mouse)Lysate at 40 ug
Cerebrum (Mouse)Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
Sample:
DU145 (Human)Cell Lysate at 40 ug
A549 (Human) Cell Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
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