Anti-MDR1 antibody (bs-20621R)

Anti-MDR1 antibody 

DATASHEET

Host:Rabbit

Target Protein:MDR1

IR:Immunogen Range:51-150/1276

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:18669

Swiss Prot:P08183

Source:KLH conjugated synthetic peptide derived from mouse MDR1:51-150/1276 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

Size:100ul

Concentration:1mg/ml

Applications:WB(1:500-2000)

Cross Reactive Species:Human
Mouse
.

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Sample:
HepG2(Human) Cell Lysate at 40 ug
Primary: Anti-MDR1 (bs-20621R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 141 kD
Observed band size: 134 kD

Sample:
Hela(Human) Cell Lysate at 40 ug
Primary: Anti-MDR1 (bs-20621R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 141 kD
Observed band size: 134 kD