Anti-IL-4R antibody
| 英文名称 | IL-4R |
| 中文名称 | 白细胞介素4受体抗体 |
| 别 名 | CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha. |
DATASHEET
Host:Rabbit
Target Protein:IL-4R
IR:Immunogen Range:71-170/825
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3566
Swiss Prot:P24394
Source:KLH conjugated synthetic peptide derived from human IL-4R:71-170/825
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
Cross Reactive Species:Human
protein.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample:
Lane 1: IL-4R-His protein (1-232) Overexpression 293T (Human) Cell Lysate at 4 ug
Lane 2: IL-4R-His protein (1-232) Overexpression 293T (Human) Cell Lysate at 4 ug
Primary:
Lane 1: Anti-IL-4R (bs-22901R) at 1/1000 dilution
Lane 2: Anti-His tag (bsm-33004M) at 1/1000 dilution
Secondary:
Lane 1: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Lane 2: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 43-48 kD
Observed band size: 43-48 kD
Sample:
Lane 1: A431 (Human) Cell Lysate at 30 ug
Lane 2: 293T (Human) Cell Lysate at 30 ug
Lane 3: Raji (Human) Cell Lysate at 30 ug
Lane 4: Jurkat (Human) Cell Lysate at 30 ug
Primary: Anti-IL-4R (bs-22901R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 140-160 kD
Observed band size: 150 kD
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