Anti-Gemin 2 antibody
| 英文名称 | Gemin 2 |
| 中文名称 | 运动神经元存活蛋白结合蛋白1抗体 |
| 别 名 | Component of gems 2; GEMI2_HUMAN; Gemin-2; gemin2; SIP 1; SIP-1; SIP1; SIP1 delta; SMN interacting protein 1; SMN interacting protein 1 delta; SMN-interacting protein 1; Survival interacting protein 1; Survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1. survival of motor neuron protein interacting protein 1; SMN protein interacting protein 1; KIAA0569; SIP 1; SIP1; SMADIP 1; SMADIP1. |
DATASHEET
Host:Rabbit
Target Protein:Gemin 2
IR:Immunogen Range:51-150/280
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8487
Swiss Prot:O14893
Source:KLH conjugated synthetic peptide derived from human SIP1:51-150/280
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Smad Interacting Protein 1 (SIP1) is observed in neural crest derived cells (peripheric nervous system, enteric nervous system, facial neurectoderm and cranial nerve ganglia), central nervous system, genital tubercle, muscles and kidneys in the developing human. SIP1 belongs to the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins and contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1 can be induced by TGF. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease. SIP1 is also involved in the regulation of epithelial to mesenchymal transition, an important process in tumor progression.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
Horse
Rabbit
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Tissue/cell: rat colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-SIP1 Polyclonal Antibody, Unconjugated(bs-1130R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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