Anti-phospho-CYLD (Ser418) antibody (bs-3080R)

Anti-phospho-CYLD (Ser418) antibody

DATASHEET

Host:Rabbit

Target Protein:phospho-CYLD (Ser418)

IR:Immunogen Range:FH(p-S)LP

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:1540

Swiss Prot:Q9NQC7

Source:KLH conjugated Synthesised phosphopeptide derived from human CYLD around the phosphorylation site of Ser418:FH(p-S)LP 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Defects in CYLD are the cause of familial cylindromatosis (CYLD) also known as turban tumor syndrome or dermal eccrine cylindromatosis. CYLD is an autosomal dominant and highly tumor type-specific disorder. The tumors (known as cylindromas because of their characteristic microscopic architecture) are believed to arise from or recapitulate the appearance of the eccrine or apocrine cells of the skin that secrete sweat and scent respectively. Cylindromas arise predominantly in hairy parts of the body with approximately 90% on the head and neck. The development of a confluent mass which may ulcerate or become infected has led to the designation "turban tumor syndrome". The skin tumors show differentiation in the direction of hair structures, hence the synonym trichoepithelioma. CYLD has deubiquitinating activity.

Size:100ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
.

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Sample:
Lane1: Heart (Mouse) Lysate at 30 ug
Lane2: Sp2/0 (Mouse) Cell Lysate at 30 ug
Primary: Anti-phospho-CYLD(Ser418) (bs-3080R) at 1:200 dilution;
Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 3000 dilution;
Predicted band size : 105kD
Observed band size : 105kD