Anti-KCNK3 antibody
| 英文名称 | KCNK3 |
| 中文名称 | 酸敏感性钾离子通道蛋白抗体 |
| 别 名 | cTBAK 1; Acid sensitive potassium channel protein TASK 1; Cardiac two pore background K(+) channel; K2p3.1; OAT1; potassium channel, subfamily K, member 3; rTASK; TASK 1; TBAK1; TWIK related acid sensitive K+ channel; Two pore potassium channel KT3.1; KCNK3; TASK; TASK1; PPH4; TASK; TASK-1; TBAK1; KCNK3_HUMAN. |
DATASHEET
Host:Rabbit
Target Protein:KCNK3
IR:Immunogen Range:181-280/394
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3777
Swiss Prot:O14649
Source:KLH conjugated synthetic peptide derived from human KCNK3:181-280/394
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:KCNK9 or TASK-3 (TWIK-related Acid sensitive K+ channel) is a member of the potassium channel family of proteins that contain two-pore domain and four transmembrane domains. These channels are characterized as leak K+ channels that are sensitive to changes in the extracellular pH. The physiological functions of TASK channels are largely unknown; it has been proposed that they may be involved in the regulation of breathing, aldosterone secretion and anesthetic-mediated neuronal activity. They were found to act in neurons' membrane potential and in resting K+ currents. KCNK9 gene has been localized to the chromosomal region 8q24. The protein is expressed at high levels mainly in the brain and at low levels in other tissues. In contrast to normal tissues, it was found that KCNK9 is amplified in some human carcinomas such as breast, lung, colon and metastatic prostate. In 10% of breast cancer patients this gene is amplified, and in 44% the protein is over expressed. Monoclonal antibodies to KNCK9 are an important tool for studying the potassium channel family of proteins in different tissues.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample: Brain (Rat) Lysate at 40 ug
Primary: Anti-KCNK3 (bs-2963R) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution
Predicted band size: 43 kD
Observed band size: 43 kD
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