Anti-Ube2L6 antibody
| 英文名称 | Ube2L6 |
| 中文名称 | 泛素载体蛋白L6抗体 |
| 别 名 | Retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG B; RIG-B; UB2L6_HUMAN; UBCH 8; UBCH8; UBE2L6; Ubiquitin carrier protein; Ubiquitin carrier protein L6; Ubiquitin conjugating enzyme E2L 6; Ubiquitin protein ligase; Ubiquitin protein ligase L6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15 conjugating enzyme E2 L6; Ubiquitin/ISG15-conjugating enzyme E2 L6. |
DATASHEET
Host:Rabbit
Target Protein:Ube2L6
IR:Immunogen Range:21-120/153
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:9246
Swiss Prot:O14933
Source:KLH conjugated synthetic peptide derived from human Ube2L6:21-120/153
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells, either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. Ubiquitin conjugating enzyme 8 (UBC8) is an E2 enzyme involved in the ubiquitin pathway for protein degradation. Like other E2 enzymes, UBC8 forms a thioester bond with ubiquitin in an E1-dependent manner. UBC8 binds to the human homolog of Drosophila ariadne (HHARI) and UBC7-associated protein (H7-AP1) as well as double ring-finger protein (Dorfin). UBC8 is enriched in the central nervous system and interacts with Parkin, a RING-finger-containing protein implicated in the pathogenesis of familial Parkinson’s disease. Parkin shares sequence homology with other UBC8 binding proteins such as HHARI and H7-AP1.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Ube2L6 Polyclonal Antibody, Unconjugated(bs-8369R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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