Anti-GPR109A antibody
| 英文名称 | GPR109A |
| 中文名称 | G蛋白偶联受体109A抗体 |
| 别 名 | HM74A; G-protein coupled receptor 109A; GPR109A; HM74a; HM74b; NIACR1; Puma-g; PUMAG; Niacr1; Niacin receptor 1; Nicotinic acid receptor; G-protein coupled receptor 109; G-protein coupled receptor HM74; G protein coupled receptor HM74a; G protein coupled receptor Hm74b; Protein PUMA-G; Interferon gamma inducible gene Puma g; Nicotinic acid receptor 1; Nicotinic acid receptor; Puma g; Pumag; rHM74b; HCAR2_HUMAN . |
DATASHEET
Host:Rabbit
Target Protein:GPR109A
IR:Immunogen Range:1-33/363
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:338442
Swiss Prot:Q8TDS4
Source:KLH conjugated synthetic peptide derived from human GPR109A/HM74A:1-33/363
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroJNCbutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Cow
Rabbit
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample:
Skin (Mouse) Lysate at 40 ug
Primary: Anti-GPR109R (bs-10079R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 40 kD
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