Anti-SCNN1D antibody
| 英文名称 | SCNN1D |
| 中文名称 | 上皮钠离子通道蛋白D/δENaC抗体 |
| 别 名 | Amiloride sensitive sodium channel subunit delta; Delta ENaC; Delta NaCH; Delta-ENaC; Delta-NaCH; DNACH; ENaC Delta; ENACD; ENaCdelta; Epithelial Na(+) channel subunit delta; MGC149710; MGC149711; Nonvoltage gated sodium channel 1 subunit delta; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; Sodium channel, nonvoltage gated 1, delta; SCNND_HUMAN. |
DATASHEET
Host:Rabbit
Target Protein:SCNN1D
IR:Immunogen Range:451-550/638
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:6339
Swiss Prot:P51172
Source:KLH conjugated synthetic peptide derived from human SCNN1D:451-550/638
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:SCNN1D is a subunit of the epithelial sodium channel (ENaC). ENaC has high sodium selectivity, low conductance, and amiloride sensitivity. The epithelial Na(+) channel (ENaC) regulates Na(+) homeostasis in cells and across epithelia; in the kidney, lung and colon it plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Four homologous ENaC subunits (alpha, beta, gamma, and delta) have been isolated in mammals. Combination of alpha-, beta-, and gamma-subunits or delta-, beta-, and gamma-subunits forms fully functional channels. A delta subunit can replace the alpha subunit. However, the pharmacology, sensitivity to amiloride, conductance, and ionic selectivity of the delta/beta-gamma channel are different from those of the alpha/beta-gamma channel.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Rat
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-SCNN1D Polyclonal Antibody, Unconjugated(bs-10141R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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