Anti-Factor I heavy chain antibody
| 英文名称 | Factor I heavy chain |
| 中文名称 | 补体因子I重链抗体 |
| 别 名 | Complement factor I heavy chain; Factor I heavy chain; AHUS3; C3b INA; C3b inactivator; C3B/C4B inactivator; C3BINA; CFAI_HUMAN; CFI; Complement component I; Complement control protein factor I; Complement factor I; F1; factor I; FactorI; FI; I factor; IF; KAF; Konglutinogen activating factor; Heavy chain of factor I; OTTHUMP00000219728. |
DATASHEET
Host:Rabbit
Target Protein:Factor I heavy chain
IR:Immunogen Range:261-360/582
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3426
Swiss Prot:P05156
Source:KLH conjugated synthetic peptide derived from human Complement factor I heavy chain:261-360/582
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Protein: Hela(human)cell lyates at 30ug;
HepG2(human)cell lyates at 30ug;
Primary: Rabbit Anti-Factor I heavy chain(bs-10339R) at 1:300;
Secondary: 800CW Conjugated Goat(polyclonal) Anti-Rabbit IgG(H+L) at 1: 10000;
Predicted band size:39/63 kD
Observed band size:63 kD
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