Anti-KIAA1161 antibody (bs-16992R)

Anti-KIAA1161 antibody

DATASHEET

Host:Rabbit

Target Protein:KIAA1161

IR:Immunogen Range:631-714/714

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:57462

Swiss Prot:Q6NSJ0

Source:KLH conjugated synthetic peptide derived from human KIAA1161:631-714/714 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:KIAA1161 is a 714 amino acid protein that belongs to the glycosyl hydrolase 31 family and functions as a putative glucosidase. This single-pass type II membrane protein is post-translationally phosphorylated at serine 44 and glycosylated at amino acid positions 240 and 250. The gene encoding KIAA1161 maps to human chromosome 9, which consists of about 145 million bases, comprises approximately 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Horse
Rabbit
.

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KIAA1161) Polyclonal Antibody, Unconjugated (bs-16992R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.