Anti-phospho-TPH2 (Ser19) antibody
| 英文名称 | phospho-TPH2 (Ser19) |
| 中文名称 | 磷酸化神经色氨酸羟化酶2抗体 |
| 别 名 | TPH2 (phospho S19); p-TPH2 (phospho S19); MGC138871; ADHD7; FLJ37295; HGNC:20692; MGC138872; Neuronal tryptophan hydroJNClase; NTPH; TPH 2; Tph2; TPH2_HUMAN; TRPO; Tryptophan 5-hydroJNClase 2; Tryptophan 5-monooJNCgenase 2; Tryptophan hydroJNClase 2; Tryptophan pyrrolase; Tryptophanase. |
DATASHEET
Host:Rabbit
Target Protein:phospho-TPH2 (Ser19)
IR:Immunogen Range:GF(p-S)LD
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:121278
Swiss Prot:Q8IWU9
Source:KLH conjugated synthesised phosphopeptide derived from human TPH2 around the phosphorylation site of Ser19:GF(p-S)LD
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Phenylalanine hydroJNClase (PAH), tyrosine hydroJNClase (TH), tryptophan hydroJNClase (TPH) and tryptophan hydroJNClase 2 (TPH2) comprise a small family of monooJNCgenases that catalyze the rate-limiting step in the catabolism of aromatic L-amino acids and utilize tetrahydropterine as a cofactor. TPH2 is highly expressed in the central nervous system (CNS), mainly in the brain. TPH2 catalyzes the first step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland, and may be involved in the pathology of several neuropsychiatric disorders. Glucocorticoid-mediated reduction of TPH2 is associated with the etiology of mood disorders, specifically psychotic major depression, and TPH2 may be related to dysregulation of serotonin neurotransmission in the brain which commonly leads to suicidal behavior.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Rat
Dog
Horse
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-phospho-TPH2(Ser19) Polyclonal Antibody, Unconjugated(bs-17166R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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