Anti-LMOD2 antibody (bs-18316R)

Anti-LMOD2 antibody

DATASHEET

Host:Rabbit

Target Protein:LMOD2

IR:Immunogen Range:451-547/547

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:442721

Swiss Prot:Q6P5Q4

Source:KLH conjugated synthetic peptide derived from human LMOD2:451-547/547 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Members of the Leiomodin protein family are closely related to the tropomodulin family of actin filament pointed end-capping proteins. Leiomodins are actin-binding proteins that act as strong filament nucleators in muscle cells. Leiomodin 1 is highly expressed in a variety of tissues that contain smooth muscle, therefore it is also known as smooth muscle Leiomodin, or SM-Lmod. Also designated C-Lmod, Leiomodin 3 is found in several types of fetal tissue and is involved in tropomyosin binding. Leiomodin 2, also known as C-LMOD or LMOD2, is a 547 amino acid protein that is specifically expressed in heart and skeletal muscles. Leiomodin 2 binds to tropomyosin and may block the elongation and depolymerization of actin filaments at their pointed end. Leiomodin 2 is encoded by a gene that is located near the hypertrophic cardiomyopathy locus CMH6 on chromosome 7, suggesting that Leiomodin 2 may be involved in that disease process. Leiomodin 2 is expressed as three alternatively spliced variants.

Size:100ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Horse
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Sample: Heart (mouse) Lysate at 40 ug
Primary: Anti-LMOD2 (bs-10196R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 62 kD
Observed band size: 62 kD