Anti-Mafa antibody
| 英文名称 | Mafa |
| 中文名称 | v-maf 肌腱膜纤维肉瘤癌基因同源物A抗体 |
| 别 名 | Mafa homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; Pancreatic beta-cell-specific transcriptional activator;(avian)(V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA_HUMAN. |
DATASHEET
Host:Rabbit
Target Protein:Mafa
IR:Immunogen Range:71-170/352
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:389692
Swiss Prot:Q8NHW3
Source:KLH conjugated synthetic peptide derived from human Mafa :71-170/352
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Pig
Cow
.
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Sample:
Cerebrum (Rat) Lysate at 40 ug
Lung (Mouse) Lysate at 40 ug
Spleen (Mouse) Lysate at 40 ug
Primary: Anti- Mafa (bs-22235R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 37 kD
Observed band size: 50 kD
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