Anti-Phospho-FADD (Ser191) antibody
| 英文名称 | Phospho-FADD (Ser191) |
| 中文名称 | 磷酸化Fas相关死亡结构域蛋白抗体 |
| 别 名 | FADD (phospho S191); p-FADD (phospho S191); FADD protein; Fas (TNFRSF6) associated via death domain; Fas associated via death domain; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; GIG 3; GIG3; Growth inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MGC8528; MORT 1; MORT1; FADD_MOUSE. |
DATASHEET
Host:Rabbit
Target Protein:Phospho-FADD (Ser191)
IR:Immunogen Range:NM(p-S)PV
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:14082
Swiss Prot:Q61160
Source:KLH conjugated Synthesised phosphopeptide derived from mouse FADD around the phosphorylation site of Ser191:NM(p-S)PV
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Mouse
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For research use only. Not intended for diagnostic or therapeutic use.
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