Anti-phospho-GIT1 (Tyr545) antibody
| 英文名称 | phospho-GIT1 (Tyr545) |
| 中文名称 | 磷酸化G蛋白偶联受体激酶相互作用蛋白1 |
| 别 名 | GIT1 (phospho Y545); GIT1 (phospho Tyr545); p-GIT1 (phospho-Y545); ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1. |
DATASHEET
Host:Rabbit
Target Protein:phospho-GIT1 (Tyr545)
IR:Immunogen Range:AI(p-Y)SV
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:28964
Swiss Prot:Q9Y2X7
Source:KLH conjugated synthetic peptide derived from human GIT1:AI(p-Y)SV
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
.
For research use only. Not intended for diagnostic or therapeutic use.
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