Anti-Phospho-PDPK1 (Ser393) antibody
| 英文名称 | Phospho-PDPK1 (Ser393) |
| 中文名称 | 磷酸化3磷酸肌醇依赖性蛋白激酶1抗体 |
| 别 名 | PDPK1(phospho Ser393); PDPK1(phospho S393); 3 phosphoinositide dependent protein kinase 1; hPDK 1; hPDK1; MGC20087 MGC35290; PDK 1; PDPK 1; PDPK1; PkB kinase; PkB kinase like gene 1; PkB like 1; PkB like; PRO0461; PDPK1_HUMAN. |
DATASHEET
Host:Rabbit
Target Protein:Phospho-PDPK1 (Ser393)
IR:Immunogen Range:SS(p-S)SH
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5170
Swiss Prot:O15530
Source:KLH conjugated Synthesised phosphopeptide derived from human PDPK1 around the phosphorylation site of Ser393:SS(p-S)SH
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
Size:100ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
.
For research use only. Not intended for diagnostic or therapeutic use.
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