Anti-phospho-p95 NBS1 (Ser343) antibody
| 英文名称 | phospho-p95 NBS1 (Ser343) |
| 中文名称 | 磷酸化DNA修复蛋白NBS1抗体 |
| 别 名 | p95 NBS1(phospho S343); p95 NBS1(phospho Ser343); p-p95 NBS1(phospho S343); Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 (nibrin); AT V1; AT V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; MGC93174; NBN; NBS 1; NBS; NBS1; Nibrin; Nijmegen breakage syndrome; Nijmegen breakage syndrome protein 1; p95; NBN_HUMAN; Nibrin; Nijmegen breakage syndrome protein 1. |
DATASHEET
Host:Rabbit
Target Protein:phospho-p95 NBS1 (Ser343)
IR:Immunogen Range:SL(p-S)QG
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4683
Swiss Prot:O60934
Source:KLH conjugated synthesised phosphopeptide derived from human NBS1 around the phosphorylation site of Ser343:SL(p-S)QG
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
Cross Reactive Species:Human
Rat
Rabbit
.
For research use only. Not intended for diagnostic or therapeutic use.
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