Anti-CPN2 antibody (bs-9907R)

Anti-CPN2 antibody 

DATASHEET

Host:Rabbit

Target Protein:CPN2

IR:Immunogen Range:371-470/545

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:1370

Swiss Prot:P22792

Source:KLH conjugated synthetic peptide derived from human CPN2:371-470/545 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:CPN2 is a zinc metalloprotease, and cleaves carboJNC-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM). By removing only one amino acid, CPN has the ability to change peptide activity and receptor binding. It is a 280 kDa tetrameric glycoprotein that is synthesized by the liver and secreted into the plasma. It consists of 2 identical 83 kDa regulatory subunits (CPN2) and 2 identical 50 kDa catalytic subunits (CPN1). CPN2, the 83 kDa subunit, binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit. CPN is a member of a larger family of carboJNCpeptidases, many of which also cleave arginine and lysine. Because of the highly conserved active sites and the possible redundant functions of carboJNCpeptidases, it has been difficult to elucidate the role of CPN in disease processes.

Size:100ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.