Anti-phospho-Aconitase 1 (Ser711) antibody (bs-12958R)

Anti-phospho-Aconitase 1 (Ser711) antibody

DATASHEET

Host:Rabbit

Target Protein:phospho-Aconitase 1 (Ser711)

IR:Immunogen Range:YG(p-S)RR

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:48

Swiss Prot:P21399

Source:KLH conjugated synthesised phosphopeptide derived from human Aconitase 1 around the phosphorylation site of Ser711:YG(p-S)RR 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

Size:100ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Cow
Horse
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.