Anti-Claudin 7 antibody (bs-8482R)

Anti-Claudin 7 antibody

DATASHEET

Host:Rabbit

Target Protein:Claudin 7

IR:Immunogen Range:21-100/211

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:1366

Swiss Prot:O95471

Source:KLH conjugated synthetic peptide derived from human Claudin 7:21-100/211 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (5). mRNA studies indicate that Claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis (6). The gene encoding human Claudin-7 maps to chromosome 17p13 (7).

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
Rabbit
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.