Anti-GADL1 antibody (bs-13264R)

Anti-GADL1 antibody 

DATASHEET

Host:Rabbit

Target Protein:GADL1

IR:Immunogen Range:51-150/521

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:339896

Swiss Prot:Q6ZQY3

Source:KLH conjugated synthetic peptide derived from human GADL1:51-150/521 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:There are two forms of glutamic acid decarboJNClases (GADs) that exist in brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboJNClase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 transiently activates to assist in GABA production. As a member of the group II decarboJNClase family, GADL1 (Glutamate decarboJNClase-like protein 1) is a 521 amino acid protein that utilizes pyridoxal phosphate as a cofactor for its carboJNClase activity. There are two isoforms of GADL1 that exist as a result of alternative splicing events.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Bee
.

For research use only. Not intended for diagnostic or therapeutic use.