Anti-GADL1 antibody
英文名称 | GADL1 |
中文名称 | 谷氨酸脱羧酶样蛋白1抗体 |
别 名 | GADL1; GADL1_HUMAN; Glutamate decarboJNClase like 1; Glutamate decarboJNClase-like protein 1; MGC138191; OTTHUMP00000161199; OTTHUMP00000222306. |
DATASHEET
Host:Rabbit
Target Protein:GADL1
IR:Immunogen Range:51-150/521
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:339896
Swiss Prot:Q6ZQY3
Source:KLH conjugated synthetic peptide derived from human GADL1:51-150/521
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:There are two forms of glutamic acid decarboJNClases (GADs) that exist in brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboJNClase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 transiently activates to assist in GABA production. As a member of the group II decarboJNClase family, GADL1 (Glutamate decarboJNClase-like protein 1) is a 521 amino acid protein that utilizes pyridoxal phosphate as a cofactor for its carboJNClase activity. There are two isoforms of GADL1 that exist as a result of alternative splicing events.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Bee
.
For research use only. Not intended for diagnostic or therapeutic use.
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