Anti-HECTD1 antibody (bs-15446R)

Anti-HECTD1 antibody

DATASHEET

Host:Rabbit

Target Protein:HECTD1

IR:Immunogen Range:2201-2300/2610

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:25831

Swiss Prot:Q9ULT8

Source:KLH conjugated synthetic peptide derived from human HECTD1:2201-2300/2610 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:EULIR is a major component of the ubiquitin-proteasome system and plays a role in determining the specificity of ubiquitin conjugation. It is responsible for transferring ubiquitin to targeted substrates from an E2 ubiquitin-conjugating enzyme through the intermediate formation of a thiol ester with ubiquitin. Similar to a number of other E3 ubiquitin ligases, EULIR contains an N-terminal ankyrin repeat domain, a mind bomb (mib) domain and a C-terminal HECT (homologous to E6-AP C-terminus) domain. The HECT domain is responsible for the ubiquitin ligase activity, catalyzing polyubiquitination. EULIR is ubiquitously expressed throughout early development and is important for the complete and proper closure of the neural tube. Mutations in the gene encoding EULIR can result in neural tube defects.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.