Anti-EID2 antibody (bs-13761R)

Anti-EID2 antibody 

DATASHEET

Host:Rabbit

Target Protein:EID2

IR:Immunogen Range:131-236/236

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:163126

Swiss Prot:Q8N6I1

Source:KLH conjugated synthetic peptide derived from human EID2:131-236/236 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:As a regulator of transcription via chromatin remodeling, p300 is a histone acetyltransferase that binds to adenovirus E1A protein and may play a role in its transforming capacity. EID-2 (EP300-interacting inhibitor of differentiation 2), also known as CREBBP/EP300 inhibitor 2, is a 236 amino acid nuclear protein that cooperates with EID-2B to bind to the C-terminus of p300 to inhibit its activity. It also represses MYOD-dependent transcription and muscle differentiation. By interacting with SMAD2, SMAD3 and SMAD4, EID-2 selectively blocks the formation of TGFB-induced SMAD3-SMAD4 complex, thereby repressing TGFB/SMAD3-dependent signaling. Though it is abundantly expressed in placenta, EID-2 is highly expressed in skeletal muscle, heart, liver, brain and kidney. There are two isoforms of EID-2 that are produced as a result of alternative splicing events.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.