Anti-FJNCD5/Dysadherin antibody (bs-14475R)

Anti-FJNCD5/Dysadherin antibody

DATASHEET

Host:Rabbit

Target Protein:FJNCD5/Dysadherin

IR:Immunogen Range:21-120/178

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:53827

Swiss Prot:Q96DB9

Source:KLH conjugated synthetic peptide derived from human Dysadherin:21-120/178 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFJNCD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FJNCD-domain containing ion transport regulator. Mouse FJNCD5 has been termed RIC (Related to Ion Channel). FJNCD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FJNCD1 (phospholemman), FJNCD2 (gamma), FJNCD3 (MAT-8), FJNCD4 (CHIF), and FJNCD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FJNCD1 and FJNCD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FJNCD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
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For research use only. Not intended for diagnostic or therapeutic use.