Anti-FAM162A antibody
| 英文名称 | FAM162A |
| 中文名称 | FAM162A蛋白抗体 |
| 别 名 | C3orf28; Chromosome 3 open reading frame 28; DC16; E2-induced gene 5 protein; E2IG5; F162A_HUMAN; Fam162a; Family with sequence similarity 162, member A1; Growth and transformation-dependent protein; HGTD P; HIF-1 alpha-responsive proapoptotic molecule; OTTHUMP00000215578; OTTHUMP00000215579; OTTHUMP00000215580; Protein FAM162A. |
DATASHEET
Host:Rabbit
Target Protein:FAM162A
IR:Immunogen Range:1-100/154
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:26355
Swiss Prot:Q96A26
Source:KLH conjugated synthetic peptide derived from human FAM162A:1-100/154
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:HGTD-P (human growth and transformation-dependent protein), also known as E2IG5 or FAM162A, is a 154 amino acid single-pass membrane protein belonging to the UPF0389 family. Considered a proapoptotic protein, HGTD-P is an effector of cell death induced by hypoxia-ischemia (HI) and is therefore considered a potential target in treating HI-induced brain damage. HGTD-P localizes to the mitochondria and, when overexpressed, induces the mitochondrial permeability transition by interacting with voltage dependent anion channels. HGTD-P facilitates apoptotic cell death via the mitochondrial apoptotic cascades, including permeability transition, cytochrome c release and caspase 9 activation. HGTD-P is regulated and activated by HIF-1?through a hypoxia-responsive element on the HGTD-P promoter region.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Pig
Horse
.
For research use only. Not intended for diagnostic or therapeutic use.
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