Anti-HSF5 antibody (bs-16558R)

Anti-HSF5 antibody

DATASHEET

Host:Rabbit

Target Protein:HSF5

IR:Immunogen Range:1-100/596

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:124535

Swiss Prot:Q4G112

Source:KLH conjugated synthetic peptide derived from human HSF5:1-100/596 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:HSF5 is a 596 amino acid protein that localizes to the nucleus and is thought to function as a transcription factor. Multiple isoforms of HSF5 exist due to alternative splicing events. The gene encoding HSF5 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
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For research use only. Not intended for diagnostic or therapeutic use.