Anti-Translation factor GUF1 antibody (bs-16573R)

Anti-Translation factor GUF1 antibody

DATASHEET

Host:Rabbit

Target Protein:Translation factor GUF1

IR:Immunogen Range:361-460/669

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:60558

Swiss Prot:Q8N442

Source:KLH conjugated synthetic peptide derived from human Translation factor GUF1:361-460/669 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:GUF1 is a 669 amino acid protein belonging to the GTP-binding elongation factor family and the LepA subfamily. Localizing to the mitochondrion inner membrane, GUF1 is thought to promote mitochondrial protein synthesis and binds to mitochondrial ribosomes in a GTP-dependent manner. GUF1 is suggested to catalyze a one-codon backward translocation of tRNAs on improperly translocated ribosomes, thereby acting as a fidelity factor of the translation reaction. GUF1 is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene desert (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Size:100ul

Concentration:1mg/ml

Applications:

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Rabbit
Zebrafish
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.