Anti-HPV116 gp2 antibody (bs-17385R)

Anti-HPV116 gp2 antibody

DATASHEET

Host:Rabbit

Target Protein:HPV116 gp2

IR:Immunogen Range:1-50/98

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:8223418

Swiss Prot:P03129

Source:KLH conjugated synthetic peptide derived from human HPV116 gp2:1-50/98 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription

Size:100ul

Concentration:1mg/ml

Applications:IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Human Papillomavirus (HPV).

For research use only. Not intended for diagnostic or therapeutic use.