Anti-HSBP1 antibody (bs-17396R)

Anti-HSBP1 antibody

DATASHEET

Host:Rabbit

Target Protein:HSBP1

IR:Immunogen Range:41-76/76

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:3281

Swiss Prot:O75506

Source:KLH conjugated synthetic peptide derived from human HSBP1:41-76/76 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors 1 and 2 (HSF1 and HSF2), also designated HSTF1 and HSTF2, are involved in this regulation and are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer, whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSBP1 (heat shock factor-binding protein 1), also known as HSF1BP or NPC-A-13 (nasopharyngeal carcinoma-associated antigen 13), is a 76 amino acid nuclear protein that binds HSF1 and acts as a negative regulator of the heat shock response.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
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For research use only. Not intended for diagnostic or therapeutic use.