Anti-SIGLECL1 antibody
| 英文名称 | SIGLECL1 |
| 中文名称 | 唾液酸结合性免疫球蛋白样凝集素12抗体 |
| 别 名 | FLJ38600; S2V; sialic acid binding Ig-like lectin 12 (gene/pseudogene); Sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin-like 1; Sialic acid-binding immunoglobulin-like lectins; SIG12_HUMAN; Siglec-12; Siglec-L1; SIGLEC-like 1; SIGLEC-like gene; SIGLEC-like protein 1; Siglec-XII; Siglec12; SLG. |
DATASHEET
Host:Rabbit
Target Protein:SIGLECL1
IR:Immunogen Range:81-180/827
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:89858
Swiss Prot:Q96PQ1
Source:KLH conjugated synthetic peptide derived from human SIGLECL1:81-180/827
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Size:100ul
Concentration:1mg/ml
Applications:
Cross Reactive Species:Human
Mouse
.
For research use only. Not intended for diagnostic or therapeutic use.
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