Anti-ORMDL1 + ORMDL2 + ORMDL3 antibody (bs-18035R)

Anti-ORMDL1 + ORMDL2 + ORMDL3 antibody

DATASHEET

Host:Rabbit

Target Protein:ORMDL1 + ORMDL2 + ORMDL3

IR:Immunogen Range:1-80/153

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:94101

Swiss Prot:Q9P0S3, Q53FV1, Q8N138

Source:KLH conjugated synthetic peptide derived from human ORMDL1 + ORMDL2 + ORMDL3:1-80/153 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney. ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma

Size:100ul

Concentration:1mg/ml

Applications:

Cross Reactive Species:Human
Mouse
Rat
Chicken
Cow
.

For research use only. Not intended for diagnostic or therapeutic use.