Anti-HSP90B2P antibody
| 英文名称 | HSP90B2P |
| 中文名称 | 热休克蛋白90β2抗体 |
| 别 名 | GRP94P1; Heat shock protein 90kDa beta (Grp94) member 2; HSP; HSPCP2; Putative endoplasmin like protein; Putative heat shock protein 90 kDa beta member 2; TRA1P1; TRAP1. |
DATASHEET
Host:Rabbit
Target Protein:HSP90B2P
IR:Immunogen Range:261-360/399
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7190
Swiss Prot:Q58FF3
Source:KLH conjugated synthetic peptide derived from human HSP90B2P:261-360/399
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
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For research use only. Not intended for diagnostic or therapeutic use.
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