Anti-HUCE1 antibody
| 英文名称 | HUCE1 |
| 中文名称 | 脑蛋白1抗体 |
| 别 名 | Cerebral protein 1; hypothetical protein LOC23378; KIAA0409; Nucleomethylin; Ribosomal RNA processing 8 methyltransferase homolog; Ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribosomal RNA processing protein 8; Ribosomal RNA-processing protein 8; RRP 8; RRP8; RRP8 methyltransferase homolog; RRP8_HUMAN. |
DATASHEET
Host:Rabbit
Target Protein:HUCE1
IR:Immunogen Range:131-230/456
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:23378
Swiss Prot:O43159
Source:KLH conjugated synthetic peptide derived from human HUCE1:131-230/456
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Sheep
.
For research use only. Not intended for diagnostic or therapeutic use.
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