Anti-phospho-MAPK6 (Ser189) antibody (bs-18672R)

Anti-phospho-MAPK6 (Ser189) antibody

DATASHEET

Host:Rabbit

Target Protein:phospho-MAPK6 (Ser189)

IR:Immunogen Range:HL(p-S)EG

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:5597

Swiss Prot:Q16659

Source:KLH conjugated synthesised phosphopeptide derived from human MAPK6 around the phosphorylation site of Ser189:HL(p-S)EG 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl-2 and caspase-3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK 3 gene maps to chromosome 15q21.2 and encodes a 721 amino acid protein. Function : Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.

Size:100ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
Sheep
.

For research use only. Not intended for diagnostic or therapeutic use.