Anti-NAF1 antibody
| 英文名称 | NAF1 |
| 中文名称 | 核组装因子1核糖核蛋白抗体 |
| 别 名 | H/ACA ribonucleoprotein complex non-core subunit NAF1; hNAF1; Naf1; NAF1_HUMAN; Nuclear assembly factor 1 homolog; Nuclear assembly factor 1 ribonucleoprotein. |
DATASHEET
Host:Rabbit
Target Protein:NAF1
IR:Immunogen Range:301-400/494
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:92345
Swiss Prot:Q96HR8
Source:KLH conjugated synthetic peptide derived from human NAF1:301-400/494
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:NAF1 is a 494 amino acid RNA-binding protein belonging to the NAF1 family. Encoded by a gene that maps to human chromosome 4q32.2, NAF1 associates with mature RNA in cell lysates and is essential for ribosome biogenesis, premessenger RNA splicing, stable RNA accumulation, maturation of box snoRNP complexes and telomere maintenance. NAF1 mobilizes at the site of transcription where it binds to and escorts the core protein Dyskerin between the nucleus and cytoplasm. NAF1 is replaced by GAR1, which binds competitively with NAF1, resulting in mature RNPs in Cajal bodies and nucleoli. NAF1 delocalizes to the cytoplasm during overexpression but NAF1 shuttling properties continue to be operative. Dyskeratosis congenita mutations in human telomerase RNA may affect NAF1 assembly function.
Size:100ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
.
For research use only. Not intended for diagnostic or therapeutic use.
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