Anti-PRPK antibody (bs-19406R)

Anti-PRPK antibody

DATASHEET

Host:Rabbit

Target Protein:PRPK

IR:Immunogen Range:81-180/253

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:112858

Swiss Prot:Q96S44

Source:KLH conjugated synthetic peptide derived from human PRPK:81-180/253 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:PRPK is a 253 amino acid protein kinase that phosphorylates Ser15 of p53. PRPK phosphorylation of p53 causes increased stabilization and activity of p53. CGI-121 may act as an inhibitor of the PRPK-p53 interaction, thus preventing the phosphorylation of p53. Unphosphorylated p53 is degraded by the ubiquitin-proteasome pathway, which may ultimately lead to cell proliferation. PRPK contains a protein kinase domain with a conserved catalytic core. PRPK is localized to the nucleus of the cell and is highly expressed in testis, with lower expression in heart, kidney and spleen.

Size:100ul

Concentration:1mg/ml

Applications:ELISA(1:5000-10000)

Cross Reactive Species:Human
Mouse
Rat
Dog
.

For research use only. Not intended for diagnostic or therapeutic use.