Anti-phospho-MLKL (Ser345) antibody
| 英文名称 | phospho-MLKL (Ser345) |
| 中文名称 | 磷酸化MLKL重组兔单克隆抗体 |
| 别 名 | phospho-MLKL(S345); p-MLKL(S345); MLKL(p-S345);9130019I15Rik; FLJ34389; hMLKL; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain-like protein; MLKL_HUMAN. |
DATASHEET
Host:Rabbit
Target Protein:phospho-MLKL (Ser345)
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:74568
Swiss Prot:Q9D2Y4
Source:KLH conjugated Synthesised phosphopeptide derived from mouse MLKL around the phosphorylation site of Ser352 :
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
Size:100ul
Concentration:1mg/ml
Applications:IHC-P(1:50-100)
IHC-F(1:50-100)
Cross Reactive Species:Mouse
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For research use only. Not intended for diagnostic or therapeutic use.
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