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Recombinant Human Granulocyte Colony Stimulating Factor (CHO-expressed) JNC90313

Recombinant Human Granulocyte Colony Stimulating Factor (CHO-expressed) JNC90313

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Recombinant Human Granulocyte Colony Stimulating Factor (CHO-expressed) 重组人粒细胞集落刺激因子

所有产品科研使用,仅用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务 

生物活性

Human Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine, mainly produced by monocytes and macrophages upon activation by endotoxin, TNF-α and IFN-γ. Among the family of colony-stimulating factors, Granulocyte Colony Stimulating Factor (G-CSF) is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. G-CSF is cytokine that acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. In addition it may function in some adhesion or recognition events at the cell surface. Human G-CSF is 73 % identical at the amino acid level to murine G-CSF and the two proteins show species cross-reactivity.

不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

小鼠大鼠兔豚鼠仓鼠狗重量 (kg)0.020.151.80.40.0810体表面积 (m2)0.0070.0250.150.050.020.5Km 系数36128520
动物 A (mg/kg) = 动物 B (mg/kg) × 动物 B的Km系数
动物 A的Km系数

例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。

化学数据
分子量
分子式
CAS号
纯度>97%, Endotoxin <0.2 EU/μg
溶解性(25°C)Water
Saline
PBS
储存和运输条件-20°C, sealed
常温运输及临时存放
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